Current Studies
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Study for Adults with Type 2 Diabetes
AstraZeneca has initiated the Solstice study, a global Phase 2 clinical trial evaluating an investigational type 2 diabetes medication in adults. You may be eligible to participate in this study if you:
- Are at least 18 years old
- Have been diagnosed with type 2 diabetes for at least 6 months
- Have an HbA1c between 7% and 10.5%, inclusive, despite treatment with diet and exercise alone, or in combination with metformin or a SGLT2 inhibitor medication
- Have a BMI of 23 or higher
- Have not taken any weight loss medications in the past 3 months
- Have not had, and are not planning to have bariatric surgery or fitting of a weight loss device
- Do not have type 1 diabetes
Additional criteria will be assessed to confirm eligibility.
When you eat, your body releases a hormone called GLP-1 that signals a feeling of fullness, delays gastric (stomach) emptying, and lowers blood sugar levels. The investigational drug, AZD5004, has been designed to work like GLP-1 to help lower blood sugar levels and promote weight loss.
People in the Solstice study will take either AZD5004, an approved oral diabetes medication called semaglutide, or placebo tablet(s) once a day for up to 26 weeks (approximately 6 months). There is a higher chance of receiving AZD5004 or semaglutide than placebo while in the study.